Rosie O'Donnell Reveals Weight Loss Transformation After Using Mounjaro

Rosie O'Donnell showcased her new look after losing weight with the help of the antidiabetic medication Mounjaro.

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Rosie O'Donnell is focusing on her health as she continues a new chapter abroad.

The 63-year-old shared a recent photo of herself performing standup comedy, more than two years after she began losing weight with the help of Mounjaro, an anti-Type 2 diabetes GLP-1 medication.

"I cant believe this is me now," the comedian wrote on her Instagram May 23, "#mounjaro #weightloss #bodydismorphia."

Rosie had shared insight into her health journey back in March, two months after she moved to Ireland with her youngest child Clay, 12.

"I've lost more weight here. I am on Mounjaro for my diabetes and one of the side effects is you lose weight," the actress—also mother of Parker, 30, Chelsea, 27, Blake, 25, and Vivienne, 22—said in a March 20 TikTok video. 

Rosie also said she recently went shopping in Dublin to buy herself clothes that "fit better" following her weight loss. "I'm one of those people who's always had a weight issue and now that I'm a size large, instead of an XL or a 2XL, I find it shocking."

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Rosie O’Donnell Shares Insight Into Life in Ireland After Moving Away From the U.S.

Another shocking aspect of her weight loss? Being able to wear pants without an elastic waistband again for the first time in ages.

"I've been wearing elastic-waist pants for a very long time," she said. "I didn't look at the size and I put them on and as we were leaving, they said what the size would be comparable to in America and I didn't really believe them."

Rosie began her recent health journey with Mounjaro in late 2022. Months later, she before and after pics of herself.

"One year on mounjaro #healthy #life," the former talk show host wrote on Instagram in February 2024. "RED SHIRT NOW - BLUE A YEAR AGO."

Instagram / Rosie O'Donnell

Using the medication is not the only way Rosie has dropped the pounds. The Flintstones actress has also making efforts to eat healthier, now that she—as she explained in her video—no longer has a chef at home like she did for more than two years when she lived in Los Angeles before her move to Ireland.

Rosie recently shared some insight into her current dietary habits, posting a TikTok video of herself sitting down to her first "Tiffany plate," made up of grape tomatoes, blackberries, carrots, green beans, cucumbers, olives, plus hard-boiled eggs, walnuts, Babybel reduced fat cheese, as well as chicken breast, fried mushrooms and sausages.

@rosie

my influencer era. look out world #tiffanyplate #rosieplate

♬ original sound - Rosie ODonnell

"It's on TikTok, and everybody makes their own little healthy food thing and then they eat it during the day," she said about the trend in her May 23 clip, before displaying her condiments—hummus, cottage cheese and spicy salsa.

"My influencer era," she captioned the video. "Look out world."

Read on for more celebs who have sounded off on drugs commonly used to lose weight, including Mounjaro and Ozempic...

Instagram / Rosie O'Donnell

The comedian has been on the anti-Type 2 diabetes medication Mounjaro since late 2022. In May 2025, she showcased her dramatic weight loss.

"I cant believe this is me now," Rosie wrote on her Instagram, "#mounjaro #weightloss #bodydismorphia."

Michael Buckner/Variety via Getty Images

Meghan Trainor

The couple that pees together also pokes together. Following the 2021 birth of eldest son Riley, singer Meghan Trainor and her actor husband Daryl Sabara did the 75 Hard challenge, "and, man, did we crush,” Meghan detailed during the April 9 episode of the couple’s Workin’ On It podcast. “Then, we heard more and more of our friends—and even our doctors—were on Mounjaro and Ozempic.”

They each opted to get on the lowest dose possible of Monjaro, combining the shots with exercise and balanced meals. “Daryl and I both do everything together," the "All About That Bass" singer explained. "And we started that journey.”

Instagram/Kendra Wilkinson

Kendra Wilkinson

Former Girls Next Door star Kendra Wilkinson gave one unnamed weight loss injectable a shot. Exactly one, to be precise. “I started the weight loss shots,” she wrote on her Instagram Stories in April 2025. “Only did one. Nevermind. Throwing away!!”

Ultimately, said the Playboy model, she wasn't interested in hopping into any potential health risks. “Heard too many horror stories around me,” explained the mom of two. “People end up in ER. Surgeries. No thanks.”

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Nikki Glaser

The Golden Globes host fiercly defended the use of Ozempic in March 2025, calling for people to be more open about using the medication.

“I love it. I’m like, ‘Do it,’” she said on The Tonight Show Starring Jimmy Fallon. “I have no judgment. If you want to do Ozempic, hell yeah, girl.”

She added, “I want people to feel more comfortable talking about doing it, because I feel like there's this shame,” she continued. “The shame is only from thin people who want you to stay fat. That's really where it's coming from. They're so mad that you're getting thin now, because that's all they have, right? You’re dynamic, you have a good personality, and they're so mad.”

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Brooks Nader

In December 2024, the model said she had once taken Ozempic but stopped after she started competing on Dancing With the Stars the previous fall.

"I took, like, a little bit when it first came out, and everyone was doing it," Nader told Us Weekly. "It made me really nauseous. I liked it—I am not going to lie—and when I went on Dancing with the Stars, I could not do both."

Brooks said she "lost a little bit of the motivation and the strength to work out" by taking the medication. "It was one or the other," she said, "and I picked dancing. I put the shot away."

Instagram / Bonnie Chapman

Bonnie Chapman

Dog the Bounty Hunter's daughter shared Nov. 1 that she had lost 58 pounds in 10 months thanks to a change in diet and the use of the weight loss medication Tirzepatide, adding, "I am able to look at myself in the mirror and feel so proud of where I've gotten."

But before finding the solution that works for her, she had a rough go with Ozempic. "I hated it," she revealed to E! News. "I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it."

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Jessel Taank

The Real Housewives of New York City star shot down speculation about her glow-up between seasons 14 and 15.

“I think that when you’re in reality TV, it’s so natural to be like, ‘Oh, she got plastic surgery or she did this or she’s on Ozempic,’” she told Us Weekly in October 2024. “I actually f--king hate Ozempic. I would never put needles in myself.”

Instagram / Lizzo

After several fans speculated on social media that Lizzo used Ozempic to lose weight, following a post she shared in which she showcased a slimmer figure, the Grammy winner posted this video, set to a viral TikTok sound bite of Christoph Waltz's character saying, "It's like a reward" from Django Unchained.

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Lottie Moss

Kate Moss' little sis revealed why getting on Ozempic was "the worst decision I ever made," during a September 2024 episode of her Dream On podcast. 

After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room. 

“I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that’s ever happened to me in my life,” she admitted. “My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.”

Presley Ann Photo / Shutterstock / Paul Archuleta / Getty Images

Jon Gosselin

The Jon & Kate Plus 8 alum told Page Six in April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic.

"You know what's annoying?" he said. "The regret of not starting it 10 years ago."

Nathan Congleton/NBC/NBCU Photo Bank via Getty Images

Ree Drummond

The Pioneer Woman star shared on her blog in March 2024 that her 50-pound weight loss in 2022 was not due to taking Ozempic or similar medications.

She added, "But you'll never hear a second of judgment from me about people who choose that direction!"

Todd Owyoung/NBC via Getty Images

Tracy Morgan

In August 2023, the 30 Rock alum said on Today With Hoda and Jenna that he lost weight on Ozempic because it supressed his appetite.

In March 2024, his health journey appeared to take a surprising turn. "I've learned to out-eat Ozempic," he said on The Tonight Show Starring Jimmy Fallon. "I gained 40 pounds."

Later that month, he clarified to E! News that he was joking, adding, "Ozempic did great by me and I was glad to use it."

Kevin Mazur/Getty Images for Atlantis The Royal

Caroline Stanbury

The Real Housewives of Dubai star opened up about using Ozempic after going through a "midlife crisis" at 45.

"After 40, we all know it's very, very hard to lose weight," she said in the May 22 episode of her podcast Uncut & Uncensored With Caroline Stanbury. "But I met so many 40-year-old women going, 'How have you done it?' And I don't want to lie to you, I used Ozempic, which I think is one of the best tools if you're able to use it."

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Jennifer Aydin

The Real Housewives of New Jersey star declared "I am not on Ozempic" during a July 2024 Watch What Happens Live interview before hilariously adding, "I'm on Mounjaro, okay. I'm sorry! I love being this weight, I love it! I have so much energy if you couldn't tell."

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Kandi Burruss

The Real Housewives of Atlanta alum revealed her failed attempt to lose weight with the injectable medication.

"It didn't curb my appetite. I know some people are like, ‘Oh, I can't eat.' Not me! I was eating appetizers, a regular meal and dessert, okay? It didn't stop anything for me," she shared in June 2024. "When you see it worked for other people and it doesn't work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'"

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Brooke Burke

“I can’t speak medically about it, but I do know that there’s so much information about what’s working and what’s not,” she shared during part of an interview with Fox News Digital. “I think that Ozempic has some great benefits, and I also think it has some dangers.”

Gilbert Flores/Billboard via Getty Images

Tori Spelling

The Beverly Hills, 90210 tried the drug to help her slim down after giving birth to her son Beau in 2017.

"I tried Ozempic and it didn't work for me," she shared in an April 2024 episode of her misSPELLING podcast, "so I went on Mounjaro, which did do the trick and I did lose weight."

Aaron Poole/E! Entertainment/NBCU Photo Bank

Raven-Symoné

"I think it's very important we understand certain medications are made for certain people," the actress told E! News' Francesca Amiker, "and to not take that away just for glamazon purposes."

Raven continued, "Do what you gotta do, just make sure you save the medication for the people who actually need it."

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Sharon Osbourne

The Talk U.K. host revealed in September 2023 that she shed 42 pounds after using Ozempic earlier in the year.

"Whatever you choose is up to you," she exclusively told E! News. "It's not a dirty little secret when you've taken something to help you lose weight, which is perfectly fine."

She added, "We don't have to bulls--t."

Instagram/Kelly Osbourne

Kelly Osbourne

Sharon's daughter has also weighed in on the Ozempic trend.

"I think it's amazing," the Fashion Police alum told E! News in January 2024. "There are a million ways to lose weight, why not do it through something that isn't as boring as working out?"

 

John Nacion/Variety via Getty Images

Kate Winslet

The Titanic star, who was once a target for tabloids when it came to her weight, shared what she thought about the weight loss trend.

"I actually don't know what Ozempic is," Kate admitted to The New York Times Magazine in an interview published in March 2024. "All I know is that it's some pill that people are taking or something like that."

"Oh, my God," Kate remarked after learning about the injectable. "This sounds terrible."

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Heidi Montag

The Hills star revealed in December 2023 that she'd recently lost 22 pounds—without taking Ozempic. "There's no shortcuts in life. And if you're taking that shortcut, I don't know," she told Page Six of other celebrities using the drug. "I don't want to name names or get into it, it's just nothing I would ever do."

Heidi noted, "I want something that is sustainable. I want something that does also require hard work."

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Amy Schumer

The Trainwreck star did not hold back when she called out celebrities for not being honest about using Ozempic as a weight loss tool during her June 8, 2023 appearance on Watch What Happens Live. 

"Everyone and their mom is gonna try it. Everyone has been lying saying, 'Oh, smaller portions,'" she told Andy Cohen, who has also publicly weighed in on the Ozempic craze multiple times. "Like, shut the f--k up. You are on Ozempic or one of those things, or you got work done. Just stop."

Schumer, who has been open about her past medical procedures, added, "Be real with people. When I got lipo, I said I got lipo."

She admitted to becoming "immediately invested" in Ozempic in 2022, but explained that it was not "livable" for her to take the Type 2 diabetes drug as it hindered her ability to spend time with her son Gene. 

"I was one of those people that felt so sick and couldn't play with my son," Schumer recalled. "I was so skinny, and he's throwing a ball at me and [I couldn't]."

Michael Buckner/Getty Images

Dr. Drew Pinsky

"People have a mixed feeling about interventions like this," Dr. Drew exclusively told E! News at Fox's Special Forces: World's Toughest Test season two event in Los Angeles on Sept. 12, 2023. "They're tantalized by it, but on the other hand, they have this weird judgment."

He continued, "If we have a medication that can be helpful, by all means, people should be encouraged to think about it."

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Sophie Turner

Forget winter, a hot take is coming.

The Game of Thrones alum was not shy when it came to sharing her opinion about Ozempic and its advertisements.

In an April 5, 2023 Instagram Story, the actress reposted a tweet from writer Sophie Vershbow that read, "The Ozempic ads plastered across the Times Square subway station can f--k all the way off." One ad featured in Vershbow's Twitter photos read, "One shot to lose weight," while another offered similar text, "A weekly shot to lose weight."

Turner adding her own commentary, writing, "WTF."

Ozempic maker Novo Nordisk previously told E! News that the drug is not FDA-approved for chronic weight management.

"While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, Novo Nordisk does not promote, suggest, or encourage off-label use of our medicines and is committed to fully complying with all applicable U.S. laws and regulations in the promotion of our products," the Danish pharmaceutical company said in a statement. "We trust that healthcare providers are evaluating a patient's individual needs and determining which medicine is right for that particular patient."

Mat Hayward/Variety via Getty Images

Chelsea Handler

Ozempic is no laughing matter for the comedian. Handler revealed her "anti-aging doctor" prescribed the medication without her realizing what the drug was.

"I didn't even know I was on it," she said during the Jan. 25, 2023 episode of Call Her Daddy. "She said, 'If you ever want to drop five pounds, this is good.'"

But while she tried the drug, Handler noted that she didn't like how it made her feel.

"I came back from a vacation and I injected myself with it," she recalled. "I went to lunch with a girlfriend a few days later, and she was like, 'I'm not really eating anything. I'm so nauseous, I'm on Ozempic.' And I was like, 'I'm kind of nauseous too.' But I had just come back from Spain and was jet-lagged."

Ultimately, Handler stopped using the drug because it wasn't medically necessary for her, adding that she gave away the remaining doses to friends.

"I've injected about four or five of my friends with Ozempic, because I realized I didn't want to use it because it was silly," she said. "It's for heavy people. I have people coming over to my house, and I'm like, 'OK, I can see you at 1, I can see you at 2.'"

Evan Agostini/AP/Shutterstock

Khloe Kardashian

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

"Let's not discredit my years of working out," Kardashian wrote on a January 2023 post. "I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people."

Trae Patton/E! Entertainment

Dr. Terry Dubrow

In addition to embracing the weight-loss drug, Dubrow actually revealed in January 2023 he temporarily used Mounjaro to learn how it affects the body.

"I thought it was amazing," the Botched star shared. "I didn't have that much weight to lose. But I wanted to try it because so many of my patients were on it and I wanted to see what it was like when you're not diabetic and you only have 10 to 15 pounds to lose."

Although Dr. Dubrow didn't disclose how much weight he lost or how long he took the medication for, he confirmed he's no longer using it.

"I thought, 'You know what, I kind of want to get my appetite back,'" he explained the reason for quitting the medication, noting he also experienced "low-grade nausea."

Ella Hovsepian/Getty Images

Kyle Richards

The Real Housewives of Beverly Hills star got real about claims that she was taking the medication after her followers on social media took notice of her weight loss.

Richards wrote back to one user under a Jan. 5, 2023 snap on Instagram of herself and her girlfriends after a workout, "I am NOT on ozempic." In another response, Richards added, "Never have been."

That wouldn't be the last time the Bravo star shot down the rumors, reiterating that she is "NOT taking" the medication under a Jan. 16, 2023 post on Instagram by Page Six. 

Amy Sussman/Getty Images

Jessica Simpson

After fans questioned whether or not she was taking Ozempic, Jessica set the record straight.

"Oh Lord," she told Bustle in an interview published July 6, 2023. "I mean, it is not [Ozempic], it's willpower. I'm like, do people want me to be drinking again? Because that's when I was heavier. Or they want me to be having another baby? My body can't do it."

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