Joe Biden's Cancer Diagnosis and Family Losses Over the Years
Joe Biden faced family tragedies, health challenges including brain surgery and prostate cancer and withdrew from the 2024 election due to concerns
Former President Joe Biden and his family have endured several tragedies over the years.
Biden married his first wife, Neilia Hunter, in 1966. The couple shared two sons, Joseph âBeauâ Biden III and Hunter Biden, and a daughter, Naomi âAmyâ Biden.
Weeks after Joe was elected to the Senate in 1972, Neilia and their three kids were involved in a car accident. Beau and Hunter survived the crash but Neilia and Amy tragically died.
Years after mourning his wife and daughter, Joe met Jill Biden. The couple wed in 1975 and welcomed daughter Ashley Biden in 1981.
Throughout his struggles, Joe remained a dedicated public servant. He served as a Senator from 1973 to 2009 before becoming Barack Obamaâs vice president. In 2020, Joe was elected as the 46th president of the United States.
Joe initially was going to run for a second term. However, in July 2024, Joe withdrew from the election after he received concerns from the public about his age and health. (Joe was 81 years old at the time.)
In May 2025, news broke that Joe was diagnosed with prostate cancer.
Keep scrolling to see the tragedies that Joe and his family have endured over the years:
Neilia Hunter and Naomi Bidenâs DeathsIn December 1972, Neilia, Amy, Beau and Hunter were involved in a car accident while Christmas shopping. The Biden familyâs station wagon was hit by a tractor-trailer after Neilia accidentally drove into the path of the oncoming vehicle.
Neilia, Amy, Beau and Hunter were pulled from the wreckage and rushed to Wilmington General Hospital. Neilia and Amy were pronounced dead on arrival. They were 30 and 13 months, respectively.
Bidenâs sons survived the accident but sustained injuries. Beau had a broken leg while Hunter had a fractured skull.
âThe pain ⌠seemed unbearable in the beginning, and it took me a long time to heal, but I did survive the punishing ordeal,â Joe wrote of the tragedy in his 2017 memoir, Promise Me, Dad. âI made it through, with a lot of support, and reconstructed my life and my family.â
Joe Bidenâs Brain SurgeriesIn 1988, Joe began to suffer from severe neck pain, which was caused by a leaking intracranial berry aneurysm. While recovering from surgery, Joe suffered from a pulmonary embolism. The procedures and recovery kept Joe away from the Senate for seven months.
Beau Bidenâs Cancer Battle and DeathIn 2013, Beau was diagnosed with glioblastoma multiforme, which is a type of cancer that starts as a growth of cells in the brain or spinal cord, per Mayo Clinic. Beau underwent surgery to remove a lesion. He also completed radiation and chemotherapy treatments.
Two years after his diagnosis, Beau died following a recurrence of brain cancer. He was 46.
Hunter Bidenâs Substance Abuse Struggles Getty ImagesHunter shared in his 2021 memoir, Beautiful Things, that he battled addiction throughout his adult life. He shared that his struggles started with alcohol when he was a teen before turning to crack cocaine. Hunter explained that he believed his struggle stemmed from losing his mother and sister.
âThere were also times, I have to admit, when I felt as if no one else could understand my pain. It seemed narcissistic even to contemplate. Yet that didnât make it feel any less true,â he penned. âBelieving that your pain is exceptional doesnât lessen anyone elseâs. Pain is our universal condition. People can go through life without finding love, but no one lives long without experiencing real hurt. It can connect us or isolate us.â
Hunter has sought treatment for his addiction struggles and faced several legal issues.
Joe Bidenâs Withdrawal From the 2024 ElectionIn July 2024, Joe announced that he was withdrawing from the 2024 presidential election after the public raised concerns about his age and health following a debate against Donald Trump.
âIt has been the greatest honor of my life to serve as your President. And while it has been my intention to seek reelection, I believe it is in the best interest of my party and the country for me to stand down and to focus solely on fulfilling my duties as President for the remainder of my term,â he wrote in a letter shared via X.
Joe subsequently endorsed his vice president, Kamala Harris, to run in his place. Harris ultimately lost to Trump.
Joe Bidenâs Cancer Diagnosis Bruce Glikas/WireImageMonths after leaving the White House, Joe was diagnosed with an âaggressiveâ form of prostate cancer.
âLast week, President Joe Biden was seen for a new finding of a prostate nodule after experiencing increasing urinary symptoms,â read a May 2025 statement from Bidenâs personal office to CNN. âOn Friday, he was diagnosed with prostate cancer, characterized by a Gleason score of 9 (Grade Group 5) with metastasis to the bone.â
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The statement added that Joe and his family were âreviewing treatment options with his physicians.â
After news broke about his condition, Joe took to social media to break his silence.
âCancer touches us all,â he captioned a May 2025 Instagram post. âLike so many of you, Jill and I have learned that we are strongest in the broken places. Thank you for lifting us up with love and support.â
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